Cook the Beef: Heat a large skillet over medium-high heat. Add ground beef and season with salt, pepper, garlic powder, onion powder, and Worcestershire sauce. Cook until browned, about 6-8 minutes. Drain excess fat and let cool slightly.
Mix Filling: In a large bowl, combine cooked beef, cheddar cheese, mozzarella cheese, crumbled bacon, diced pickles, and caramelized onions. Mix well.
Prepare Dough: Separate biscuit dough into individual pieces (or cut pizza dough into 16 equal squares). Flatten each piece slightly.
Fill and Seal: Place 2 tablespoons of filling in the center of each dough piece. Pull edges up and pinch together to seal completely. Roll into a smooth ball.
Preheat and Arrange: Preheat oven to 375 degrees F (190 degrees C). Line a baking sheet with parchment paper. Place bombs seam-side down, spacing 2 inches apart.
Make Garlic Butter: Melt butter and stir in minced garlic.
Brush and Top: Brush each bomb with garlic butter. Sprinkle with Parmesan cheese and parsley.
Bake: Bake for 15-18 minutes until golden brown and cooked through.
Cool and Serve: Let cool for 3-5 minutes before serving.